文章基本信息

标题：Studies on the Syntheses of Hydrogenated Quinolines and Isoquinolines as Analgesics. XI. Synthesis of N-Methyl-6-aza-des-N-morphinan (2-Methyl-5, 10b-trimethylene-1, 2, 3, 4, 4a, 5, 6, 10b-octahydrobenzo [h] isoquinoline).
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作者：Norio Sugimoto ; Susumu Ohshiro ; Hiroshi Kugita 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：1957
卷号：5
期号：1
页码：62-67
DOI：10.1248/cpb1953.5.62
出版社：The Pharmaceutical Society of Japan
摘要：Synthesis of a morphinan analog in which the ring nitrogen was transposed to 6-position has been described. A benzyl group was introduced into 5-position of 5, 6, 7, 8-tetrahydroisoquinoline, whose methohalide was reduced to the octahydroisoquinoline, and the objective compound was obtained by heating the latter in hydrobromic acid to effect rearrangement-cyclization.