文章基本信息

标题：Studies on Terramycin and Related Compounds. IX. Synthesis of 3-(o-Carboxy-phenyl) butyric Acid via the Reformatsky Reaction.
本地全文：下载
作者：Zenichi Horii ; Ichiya Ninomiya ; Yasumitsu Tamura 等
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：1957
卷号：5
期号：1
页码：6-10
DOI：10.1248/cpb1953.5.6
出版社：The Pharmaceutical Society of Japan
摘要：The Reformatsky reaction of ethyl o-acetylbenzoate (II) with ethyl bromoacetate gave ethyl 3-methylphthalide-3-acetate (IIIa) as the product, which was led to 3-(o-car-boxyphenyl) butyric acid (I) via 3-(o-carboxyphenyl) crotonic acid (IVa). The structures of (IIIa) and (IVa) were established by means of their chemical properties and the ultraviolet and infrared absorption spectra, and it was shown that the method was valuable for the verification of each structure of the tautomerism represented by the following general formulae : [chemical formula]