文章基本信息

标题：Studies on the Allied Compounds of Vitamin B1. XX. The Structure of Dihydrothiamine. (1)
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作者：Shigeru Yoshida ; Mitsuru Kataoka
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：1957
卷号：5
期号：2
页码：176-180
DOI：10.1248/cpb1953.5.176
出版社：The Pharmaceutical Society of Japan
摘要：1) From the infrared absorption spectral examination of normal- and iso-dihydrothiamine and related compounds (VII), it was confirmed that the structure of normal- and iso-dihydrothiamine should not be represented by the hitherto used structural formula (I) but by (II) from the fact that these compounds show absorption of an amino group but not of hydroxyl group and absorptions at 1030 and 840 cm^-1 of characteristic ring vibration. 2) 3-Benzyl-3a-methyl-perhydrofuro[2, 3-d]thiazole compounds (VII) were synthesized by the reduction of benzylthiazolium compounds (VIII) with lithium aluminum hydride or sodium borohydride, or by the condensation of benzylamine, formaldehyde, and 3-acetyl-3-mercaptopropanol.