文章基本信息

标题：Chemicopharmacological Studies on Antispasmodic Action. VII. Antagonism to Acetylcholine tested with Rectus Abdominis of Frog.
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作者：Keijiro Takagi ; Issei Takayanagi
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：1957
卷号：5
期号：3
页码：247-253
DOI：10.1248/cpb1953.5.247
出版社：The Pharmaceutical Society of Japan
摘要：It was concluded statistically on the contraction of rectus abdominis of a frog that : 1) The reaction between ACh and its receptor in the muscle obeyed Clark's formula and the reaction order was 1, that is, they react with one molecule each. 2) Reaction mechanism between ACh and its receptor was different in the presence of eserine, from that in its absence. 3) Antagonism of atropine and d-tubocurarine to ACh obeyed Gaddum's formula as competitive. 4) One molecule of d-tubocurarine antagonized two mo■ecules of ACh ; two ammonium nitrogens in d-tubocurarine antagonized one molecule of ACh each.