文章基本信息

标题：The Synthesis of 8-Substituted Purine Derivatives. I. Some 8-Substituted Derivatives of Hypoxanthine.
本地全文：下载
作者：Morizo Ishidate ; Hidetaka Yuki
期刊名称：Chemical and Pharmaceutical Bulletin
印刷版ISSN：0009-2363
电子版ISSN：1347-5223
出版年度：1957
卷号：5
期号：3
页码：240-244
DOI：10.1248/cpb1953.5.240
出版社：The Pharmaceutical Society of Japan
摘要：Some hypoxanthine derivatives which were substituted at C₈-position by hydrophilic groups such as-SH, -S-CH₂-COOH, -COOH, -CH₂OH and-CH₂-CH₂-COOH were synthesized for testing purine-antagonist action. They were prepared by condensation of 4, 5-diamino-6-hydroxypyrimidine (I) with the corresponding acid or amide compounds through the acyl derivatives of (I). A direct preparation of 4-amino-6-hydroxypyrimidine by reaction of malonamamidine with ethyl formate was also described.