文章基本信息

标题：リゼルグ酸およびクラビンアルカロイドの人血清コリンエステラーゼ阻害作用について
本地全文：下载
作者：丹羽口徹吉 ; 井上堯子
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1969
卷号：15
期号：5
页码：286-289
DOI：10.1248/jhs1956.15.286
出版社：The Pharmaceutical Society of Japan
摘要：The inhibition of human serum cholinesterase by lysergic acid diethylamide (LSD), lysergic acid amide (LAA), isolysergic acid amide (iso-LAA), lysergol and elymoclavine was investigated, acetylcholine was used as a substrate. The enzyme activity was assayed by colorimetric determination of residual acetylcholine in the incubation mixture. The 50 percent inhibition of the cholinesterase activity in human serum was observed with 6×10^-4μM LSD, 3×10^-2μM elymoclavine and 1×10^-1μM lysergol. Only 20 per cent inhibition occurred with concentration of LAA or iso-LAA up to 2×10^-1μM. These alkaloids were the competitive inhibitors of the enzyme to acetylcholine.