文章基本信息

标题：質量分析法によるバルビツール酸系催眠薬およびその体内代謝産物の確認
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作者：水柿道直 ; 鈴木康男 ; 内山充等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1971
卷号：17
期号：4
页码：241-244
DOI：10.1248/jhs1956.17.241
出版社：The Pharmaceutical Society of Japan
摘要：As a practical application of mass spectrometry in forensic chemistry, mass spectra of eleven kinds of barbiturates including their metabolites were measured. Initial fragmentation of the barbiturates was classified into two large patterns : (a) elimination of the 5'-substituent as an olefin molecule (barbital, phenobarbital, amobarbital, etc.), and (b) elimination of the 5'-substituent as a radical (ethylhexabital, methylhexabital, allobarbital, etc.). Identification of ethylhexabital and its metabolites extracted from urine after administration of ethylhexabital was successfully made by the combination of thin-layer chromatography and mass spectrometry.