文章基本信息

标题：メチルコバラミン(ビタミンB12アナローグ)による無機水銀の化学的メチル化反応
本地全文：下载
作者：井村伸正 ; 助川英治 ; 彭秀光等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1971
卷号：17
期号：5
页码：353-356
DOI：10.1248/jhs1956.17.353
出版社：The Pharmaceutical Society of Japan
摘要：Chemical methylation of inorganic mercurial compounds with methylcobalamin, a vitamin B₁₂ analog, was examined. Quantitative determination of methylated mercury by gas chromatography and analysis of the products by thin-layer chromatography revealed that thh methylation proceeded at a markedly high rate by simply mixing methylcobalamin with inorganic mercury, and the reaction gave dimethylmercury as the initial and methylmercury as the final products. Comparative experiments using several other metal halides under the same condition indicated that mercuric chloride is a unique acceptor of the methyl moiety from methylcobalamin among these metal halides tested.