文章基本信息

标题：有害性金属の衛生化学的研究(第3報)カドミウム投与時における, カドミウムの体内分布, 排泄と生体におけるカルシウムおよびリン酸の消長について
本地全文：下载
作者：安藤正典 ; 佐谷戸安好 ; 外村正治等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1973
卷号：19
期号：2
页码：73-81
DOI：10.1248/jhs1956.19.73
出版社：The Pharmaceutical Society of Japan
摘要：Following the preceeding work on the acute and subacute toxicity tests of cadmium chloride, metabolism and organ distribution of cadmium chloride in rats were investigated after continuous oral administration of 5 or 20 mg/kg/day of cadmium chloride for 30 days. Most of the administered cadmium chloride was excreted in feces and only less than 0.1% was detected in urine. The amount of accumulation of cadmium chloride was highest in the liver, followed by kidney, pancreas, and spleen in that order. Examination of calcium and phosphate excreted in urine and feces showed that the amount of discharged calcium increased markedly in proportion to that taken, while the amount of phosphate excreted in urine and feces decreased. As for the distribution pattern of calcium and phosphate, a clear change could not be observed in the group administered cadmium.