文章基本信息

标题：人工細胞内, 外液における水銀化合物とL-トリプトファンあるいはアデノシンとの結合物形成
本地全文：下载
作者：奥田潤 ; 都築裕治
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1978
卷号：24
期号：1
页码：29-35
DOI：10.1248/jhs1956.24.29
出版社：The Pharmaceutical Society of Japan
摘要：Complex formation of L-tryptophan (Trp) or adenosine (Ado) with mercuric chloride (MC) or methylmercuric chloride (MMC) was examined in an artificial intracellular fluid (pH 8.0) and artificial extracellular fluid (pH 8.0). 1) A strong complex formation of L-tryptophan or adenosine with mercuric chloride was demonstrated in the artificial intracellular fluid containing oxianions (HPO^2-₄, HCO^-₃), while the complex formation in the artificial extracellular fluid was considerably weak, because of the high concentiation (110 mM) of chloride ion in this fluid. 2) Dissociation constants (K) of complexes of [MC·Trp], [MC·trptamine], [MC·indole], and [MC·Ado] were found to be 1.83×10^-3M, 7.60×10^-4M, 1.22×10^-5M, and 2.30×10^-2M, respectively, in phosphate buffer (32 mM, pH 8.0). 3) The complex formation of L-tryptophan or adenosine with methylmercuric chloride in the artificial intra or extra cellular fluid was much weaker than that with mercuric chloride.
关键词：L-tryptophan;adenosine;mercuric chloride;methylmercuric chloride;artificial intracellular fluid;artificial extracellular fluid;dissociation constant