文章基本信息

标题：有害性金属の衛生化学的研究(第7報)カドミウム連続経口投与時の骨構成成分ならびに酵素活性について
本地全文：下载
作者：安藤正典 ; 佐谷戸安好 ; 大沢利昭等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1978
卷号：24
期号：1
页码：19-24
DOI：10.1248/jhs1956.24.19
出版社：The Pharmaceutical Society of Japan
摘要：Chemical composition of the bone and the activity of the enzyme responsible for bone resorption in rats were examined after oral administration of cadmium chloride for various lengths of time. The amount of sialic acid and hexose in the bone of rats treated with cadmium increased over that of control rats, but the amount of hexosamine and uronic acid did not change. The amounts of calcium and phosphorus in the bone decreased markedly after exposure of the animals to cadmium chloride for 6 months. In the rats which treated with cadmium for 6 months, the activities of acid phosphatase, β-glucuronidase, β-N-acetylglucosaminidase, and β-galactosidase in the bone all increased over those of the control rats. These results suggested that resorption of diaphysial bone of rats were accelerated by the continuous oral ingestion of cadmium.
关键词：cadmium;poisonous effect of cadmium;chemical composition in bone;activity of enzyme in bone;bone resorption