文章基本信息

标题：ドデシル硫酸ナトリウムの長期毒性試験
本地全文：下载
作者：福沢健治 ; 徳村彰 ; 山田貞二等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1978
卷号：24
期号：2
页码：107-110
DOI：10.1248/jhs1956.24.107
出版社：The Pharmaceutical Society of Japan
摘要：Weanling male rats were bred with a drinking water containing sodium dodecyl sulfate (SDS) at concentrations of 0.25, 0.05, or 0% for 5 months. Increase of organ weights was observed in the lung and kidney, though body weight was not affected at a higher concentration (0.25%). Histopathology of major organs indicated the characteristic symptom to be bronchopneumonia by the continued ingestion of a small amount of SDS. Activities of serum enzymes, such as GOT, GPT, alkaline phosphatase, and cholinesterase, were not affected at the dosages used. In rats taking 0.25% of SDS, triglyceride level increased in the liver but decreased in serum, while hepatic and serum levels of cholesterol, phospholipid, and free fatty acid were unchanged.
关键词：sodium dodecyl sulfate;chronic toxicity;histopathology;bronchopneumonia;serum enzyme;tissue lipid