文章基本信息

标题：セレンによる水銀の減毒作用に関する研究(第4報)メチル水銀の毒性に対する各種セレン化合物の減毒効果と水銀およびセレンの体内分布の関係
本地全文：下载
作者：小宮和英 ; 大高順子 ; 河内佐十等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1978
卷号：24
期号：4
页码：163-169
DOI：10.1248/jhs1956.24.163
出版社：The Pharmaceutical Society of Japan
摘要：The protective effect of six selenium compounds (sodium selenite, sodium selenate, selenocystine, selenocysteamine, selenocystamine, and selenomethionine) on the acute toxicity of methylmercuric chloride on rats was compared on the basis of survival rate and body weight change. Distribution of mercury and selenium in the rat tissues 24 hr and 1 week after the simultaneous injection of methylmercuric chloride and various selenium compounds was determined by non-destructive neutron activation analysis. All of the six selenium compounds were found to have some protective effect on the acute toxicity of methylmercuric chloride. The protective effect of six selenium compounds decreased in the order of selenomethionine, sodium selenate, selenocysteamine, selenocystine, selenocystamine, and sodium selenite. Correlation between the distribution of mercury and selenium was rarely found in the animals given simultaneous injection of methylmercuric chloride and various selenium compounds. This result suggests that the protective effect of selenium is not due to the direct binding of methylmercury and selenium.
关键词：methylmercuric chloride;selenite;selenate;selenocystine;selenocysteamine;selenocystamine;selenomethionine;methylmercury toxicity protection by selenium compounds