文章基本信息

标题：高速液体クロマトグラフ法による混合製剤の分析(第6報)解熱鎮痛剤配合製剤の高速液体クロマトグラフィーによる定量
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作者：立沢政義 ; 松田りえ子 ; 山宮卓二等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1979
卷号：25
期号：5
页码：284-288
DOI：10.1248/jhs1956.25.284
出版社：The Pharmaceutical Society of Japan
摘要：A rapid and sensitive high-speed liquid chromatographic assay was developed for aspirin, aspirin aluminium, salicylic acid, acetaminophen, aminopyrine, and sulpyrine in antipyretic preparations. Aspirin, salicylic acid, acetaminophen, aminopyrine, and sulpyrine were separated by injection of the solution into a column (50 cm×3 mm i.d.) packed with Hitachi Gel 3011. Aspirin, salicylic acid, and acetaminophen were eluted with methanol-glacial acetic acid (99 : 1) and detected at 280 and 310 nm. Aminopyrine was eluted with methanol-28% ammonia water (99 : 1) and detected at 280 nm. Aspirin aluminium was dissolved in methanol-phosphoric acid (99 : 1) at 50°to prepare a sample solution.
关键词：high speed liquid chromatography;antipyretics;aspirin;aspirin aluminium;salicylic acid;acetaminophen;aminopyrine;sulpyrine