文章基本信息

标题：ブチルスズ化合物のラット分離肝細胞における代謝
本地全文：下载
作者：兼俊明夫
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1983
卷号：29
期号：5
页码：303-311
DOI：10.1248/jhs1956.29.5_303
出版社：The Pharmaceutical Society of Japan
摘要：The cytotoxicity and metabolism of four butyltin compounds were examined on isolated viable rat hepatocytes. Of the compounds tested, tributyltin exhibited the most potent cytotoxicity and was metabolized with the fastest rate by rat hepatocytes. These actions of tributyltin would be due to the high affinity for rat hepatocyte. The formation of dibutyltin, monobutyltin and inorganic tin as metabolites of tributyltin was observed. However, in the case of tetrabutyltin, detectable metabolite was only monobutyltin. Cytochrome P-450 associated with the metabolism of butyltin compounds was induced by phenobarbital, but not by 3-methylcholanthrene. No metabolism of tributyltin was detected in isolated viable rat kidney cells. Therefore, it would be suggested that the contribution of liver was much larger than that of kidney on the metabolism of butyltin compounds in vivo.
关键词：metabolism;tin;butyltin compounds;viable rat hepatocyte;rat kidney cell;NADPH;cytochrome P-450;phenobarbital;3-methylcholanthrene