文章基本信息

标题：家庭用品による接触皮膚炎の原因物質の追究(第5報)綿ネルの寝間着中のナフトールASによるPigmented Contact Dermatitis
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作者：小嶋茂雄 ; 鹿庭正昭 ; 中村晃忠等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1986
卷号：32
期号：5
页码：359-367
DOI：10.1248/jhs1956.32.359
出版社：The Pharmaceutical Society of Japan
摘要：In order to identify a compound as a causative agent of contact dermatitis, the following requirements should be met : 1) The patient shows positive reaction to the suspected product. 2) The product contains the candidate compound. And, 3) the patient also shows positive reaction to the candidate compound. However, it is not easy to meet these requirements without co-operations between dermatologists and chemists. Recently, we have experienced four patients of pigmented contact dermatitis from cotton flannel nightdresses, and attempted to make clear the causative agent of these dermatitis by the combination of patch testing to the patients and chemical analysis of the flannels. The results obtained could be summarized as follows : i) In patch testing, all of four patients showed positive reactions to the cotton flannel nightdresses they had worn. ii) By the chemical analyses of these flannels, it was found that these flannels contained large amounts of naphthol AS (2-hydroxy-3-naphthanilide), an azoic coupling component (contents : 2900-11700μg/g). And, iii) the patients also showed positive reactions to naphthol AS in patch testing. Since the above results satisfied the requirements 1)-3), we could conclude that naphthol AS might be the causative agent of these dermatitis.
关键词：cotton flannel nightdress;pigmented contact dermatitis;causative agent;dermatologist-chemist co-operation;patch testing;chemical analysis;naphthol AS;2-hydroxy-3-naphthanilide