文章基本信息

标题：アスファルトタールによるベンゾ〔α〕ピレンの変異活性抑制作用ベンゾ〔α〕ピレン-3-水酸化酵素の阻害
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作者：玉川勝美 ; 三島靖子 ; 関敏彦等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1986
卷号：32
期号：5
页码：344-349
DOI：10.1248/jhs1956.32.344
出版社：The Pharmaceutical Society of Japan
摘要：The effects of asphalt tar and its components on the mutagenic activity of benzo[α]pyrene (B[α]P) were studied. The mutagenic activity of B[α]P was inhibited significantly by the addition of asphalt tar and its components especially by those containing neutral polycyclic aromatic hydrocarbon which was obtained by the fractionation according to the method of Hoffmann et al. The above effects seemed to be due to the inhibition of the activating enzyme of B[α]P and it was demonstrated that the activity of B[α]P-3-hydroxylase was inhibited strongly by the neutral polycyclic aromatic hydrocarbon fraction of the asphalt tar in a competitive manner (K₁=4μg/ml).
关键词：asphalt tar;neutral polycyclic aromatic hydrocarbon;S. typhimurium TA98;benzo[α]pyrene;mutagenicity;benzo[α]pyrene-3-hydroxylase;competitive inhibition