文章基本信息

标题：セレン関連化合物に関する研究(第3報)セレン酸ナトリウムの急性ならびに亜急性毒性についてその1
本地全文：下载
作者：中室克彦 ; 佐谷戸安好 ; 外村正治等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1974
卷号：20
期号：1
页码：29-35
DOI：10.1248/jhs1956.20.29
出版社：The Pharmaceutical Society of Japan
摘要：The study was carried out to obtain the fundamental data about biological action of selenium in order to establish the standard of water quality for supply water. Following the previous examination on the body turnover, time-excretion, and distribution of ⁷⁵Se-labeled sodium selenate after a single oral administration to rats, acute and subacute toxicity of sodium selenate were examined in Wistar rats. Acute oral LD₅₀ value of sodium selenate for female rats was 31.5 mg/kg body weight, and its 95% confidence limit was 30.08-37.46 mg/kg body weight. In acute toxicity tests of sodium selenate, these rats showed decreased spontaneous movement, bristle and violent respiration, and had diarrhea, and then died of respiratory embarrassment with coordinate convulsion. The subacute toxicity of sodium selenate was examined by continuous oral administration of 1 and 5 mg/kg/day for 30 days in male and female rats. Subacute symptoms included a decrease in growth rate, inhibition of food intake, and fecal excretion. The outstanding pathological lesions were enlargement of spleen and kidney, edema of pancrease, degeneration of liver cells, bleeding foci in the liver, and a subacute yellow liver atrophy, and these appeared more evidently in female rats than in males.