文章基本信息

标题：鉛化合物投与後のラット体内における鉛の分布および排泄について
本地全文：下载
作者：丸茂義輝 ; 及川智正 ; 丹羽口徹吉等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1974
卷号：20
期号：1
页码：24-28
DOI：10.1248/jhs1956.20.24
出版社：The Pharmaceutical Society of Japan
摘要：Lead nitrate (80mg/kg Pb), lead stearate (80mg/kg Pb), and tetraethyl lead (0.3mg/kg Pb) were given to 3 separate groups of rats by a single oral administration. Difference in the distribution and excretion of lead in rats among these 3 kinds of lead compounds was examined. Atomic absorption spectrophotometry was used for the determination of lead in biological materials. After administration of lead nitrate, 92% of lead administered was excreted in the feces within 3 days. The highest distribution of lead was found in the liver (0.169±0.030%), followed by the kidney (0.153±0.018%), leg bone (0.078±0.015%), blood (0.052±0.015%), and rib (0.023±0.006%) at 7 hr after the administration. Lead distributed in the liver, kidney, and blood decreased rapidly, while that in the leg bone and rib increased up to 2 days after the administration, and then decreased slowly. After administration of lead stearate, distribution and excretion of lead were similar to those of lead nitrate. In the case of tetraethyl lead, 62% of lead was excreted in the feces during 8 days. The highest lead distribution was found in the liver throughout the experiment (27.1±3.5% after 7 hr and 12.5±3.4% after 32 days). Lead distributed in the blood, kidney, brain, leg bone, and rib increased up to 3 or 4 days after the administration. On the 32 nd day, lead in the blood and rib was almost 0%, but lead was found in the kidney (1.29±0.39%), brain (0.75±0.36%), and leg bone (3.13±1.35%).