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标题：Some Changes of Serum Lipid in Mice injected with Vibrio parahaemolyticus Endotoxin
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作者：OSAMU SAKAGUCHI ; SHUHEI SAKAGUCHI
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1976
卷号：22
期号：5
页码：303-307
DOI：10.1248/jhs1956.22.303
出版社：The Pharmaceutical Society of Japan
摘要：Some changes of serum lipid in mice were observed by the intraperitoneal injection of endotoxin extracted from Vibrio parahaemolyticus. A remarkable increase in the serum triglyceride content was shown in the poisoned mice after 12-24 hr. FFA level in the control mice gradually increased in response to the fasting periods for 12-24 hr whereas the level of FFA in the endotoxin-posioned mice was lower than that in the control mice. Total cholesterol, however, did not show an appreciable difference in the level of the control animals. The hepatic triglyceride content in the poisoned mice increased at 14 hr postintoxication, and the lysosomal triglyceride lipase activity slightly increased 3 hr after intoxication, and declined after 14 hr. There was not very much change of the triglyceride level in the serum in cortisone plus endotoxininjected mice. An increase of serum triglyceride in CCl₄-poisoned mice was not observed at 14 hr postinjection of endotoxin in spite of its high level in the serum of endotoxin-injected mice. The mechanism responsible for the development of the hypertriglyceridemia in mice after injection of endotoxin is unkown at present.