文章基本信息

标题：水銀化合物の環境衛生学的研究(第6報)妊娠ラットにおける水銀化合物の胎盤透過, 胎仔移行におよぼすシステインの影響
本地全文：下载
作者：三谷一憲 ; 中田利一 ; 小瀬洋喜等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1978
卷号：24
期号：5
页码：246-251
DOI：10.1248/jhs1956.24.246
出版社：The Pharmaceutical Society of Japan
摘要：Effect of cysteine on the transfer of mercury (methylmercury and inorganic mercury) compounds to fetus across the placenta was examined in pregnant rats. Either of 4 kinds of mercury solutions, methylmercury solution (MM), MM added with cysteine solution (MM-cys), inorganic mercury (HgCl₂) solution, and HgCl₂ added with cysteine solution (HgCl₂-cys), was injected intravenously into pregnant rats at 18 the day of gestation. After 2 hr, they were killed by blood letting from femoral vein and mercury concentration in blood, liver, kidneys, brain, placenta, and fetus was determined. In both placental and fetal mercury, MM-cys group showed significantly higher content that MM group but there was no difference between HgCl₂-cys group and HgCl₂ group. The ratio of fetal to placental mercury content in MM-cys group was significantly higher than that in MM group. These facts indicate that cysteine was one of the materials which promoted the transfer of methylmercury to fetus across the placenta.
关键词：placental transfer of mercury compounds;methylmercury;inorganic mercury;cysteine;dialysis;pregnant rat