文章基本信息

标题：酸化型染毛剤の突然変異性に関する研究(第1報)染毛剤原料の過酸化水素による酸化後の突然変異性について
本地全文：下载
作者：武田寧 ; 吉村龍子
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1978
卷号：24
期号：6
页码：322-326
DOI：10.1248/jhs1956.24.322
出版社：The Pharmaceutical Society of Japan
摘要：Bacterial mutagenicity of five hair dye intermediates was examined after oxidation by hydrogen peroxide under alkaline condition (pH>10), using Salmonella typhimurium TA98 as the tester strain. Hair dye intermediates tested were p-phenylenediamine, p-toluylenediamine, o-nitro-p-phenylenediamine, and 2, 4-diaminoanisole. In the case of oxidation of p-phenylenediamine, m-phenylenediamine, or 2, 4-diaminoanisole, the mutagenic activity of aromatic diamine varied with the amine concentration in the reaction mixture. Similar effect was also observed with hydrogen peroxide. A lower mutagenic activity was observed when a lower concentration of amine or hydrogen peroxide was employed. Such a concentration effect was not significant in the oxidation of p-toluylenediamine and o-nitro-p-phenylenediamine. In the case of oxidation of amine mixtures, the derived mutagenic activity varied markedly with the molar ratio or the concentration of constituent amines. Therefore, the mutagenic activity of oxidative hair dyes might depend not only on the kind of hair dye intermediates in hair dye preparations, but also on their concentrations.
关键词：mutagenicity;hydrogen peroxide;Salmonella typhimurium TA98;hair dye intermediates;p-phenylenediamine;p-toluylenediamine;o-nitro-p-phenylenediamine;m-phenylenediamine;2, 4-diaminoanisole;oxidative hair dye