文章基本信息

标题：外用タール色素に関する衛生化学的研究(第2報)赤色505号の異性体について
本地全文：下载
作者：早川ゆみ子 ; 宮越護 ; 永山富雄等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1984
卷号：30
期号：4
页码：211-215
DOI：10.1248/jhs1956.30.4_211
出版社：The Pharmaceutical Society of Japan
摘要：From the results of HPLC-analysis of commercial cosmetic dyes, the existence of isomers of 1-xylylazo-2-naphthol (=XAN ; Japanese recommended name : Red No. 505) based on two methylgroups was suggested. Possible six isomers of XAN (2, 3-, 2, 4-, 2, 5-, 2, 6-, 3, 4-, and 3, 5-XAN) were synthesized and applied to reversed-phase HPLC by using a Zorbax ODS column. Six isomers except 3, 4- and 3, 5-XAN could be separated. Four commercial samples of Red No. 505 in Japan were applied to this method for the determination of isomeric constitutions. Two of them were constituted of only 2, 4-XAN and other two samples were mixtures of 2, 4-, 2, 5- and 2, 6-XAN. All the six isomers and four commercial samples of XAN did not show mutagenicity by testing with S. typhimurium TA 98 and TA 100.
关键词：1-xylylazo-2-naphthol;red No.505;oil red XO;sudan II;cosmetic azo dye;reversed-phase HPLC;mutagenicity