文章基本信息

标题：Toxicologic Investigation of Dimethylacrylamide in Mice
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作者：EIICHI HAYASHI ; MASARU KUNITOMO ; MAMORU TERADA 等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1974
卷号：20
期号：6
页码：317-321
DOI：10.1248/jhs1956.20.317
出版社：The Pharmaceutical Society of Japan
摘要：Acute and subacute toxicity of dimethylacrylamide in mice was studied. LD₅₀ by a single oral dose was 485 mg/kg (male) and 460 mg/kg (female), and that by subcutaneous injection was 580 mg/kg (male) and 590 mg/kg (female). In a subacute toxicity test for a 6-week period, no adverse change attributable to the ingestion of dimethylacrylamide was observed in body weight, gross physiological appearance, and in clinical, histopathological, and hematological examinations, except a slight increase in the weight of the liver, spleen, and testis.