文章基本信息

标题：ガスクロマトグラフィーによる生体試料中の5-アリル-5-イソブチルバルビツール酸, カフェイン, アミノピリンを成分とする鎮痛剤の定量
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作者：神津公 ; 神田鷹久 ; 柳沢雄一等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1975
卷号：21
期号：2
页码：110-113
DOI：10.1248/jhs1956.21.110
出版社：The Pharmaceutical Society of Japan
摘要：Analgesic components (5-allyl-5-isobutylbarbituric acid, caffeine, and aminopyrine) in a tablet and biological materials were determined by gas-liquid chromatography with hydrogen flame ionization detector on 1.5 m glass column packed with 3.5% SE-30 at 190°. Determination was made successfuly by the internal standard method using methaqualone. These components were extracted from urine with chloroform after adjusting the pH to 8.0 with 10% ammonium hydroxide solution. The cleanup procedure suitable for the extract was carried out by the Florisil column. The components were eluted with ethyl acetate : chloroform (4 : 1) mixture. The recovery rates of allyl-isobutylbarbituric acid, caffeine, and aminopyrine added to urine were 92.9%, 95.1% and 84.0%, respectively.