文章基本信息

标题：ブロムワレリル尿素のアルカリ分解による2-Imino-5-isopropyl-4-oxazolidinoneの生成
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作者：礒野秀夫 ; 狐塚寛
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1980
卷号：26
期号：3
页码：112-117
DOI：10.1248/jhs1956.26.112
出版社：The Pharmaceutical Society of Japan
摘要：A compound having a molecular formula C₆H₁₀O₂N₂ (MW 142, mp 218°) has been known to be formed by warming α-bromoisovalerylurea (BV) with 28% aqueous ammonia. In order to determine the chemical structure of this compound, the analytical data of the compound obtained by treatment of BV with ammonia were compared with those of synthetic 5-isopropylhydantoin (C₆H₁₀O₂N₂, MW 142, mp 145-146°) and 3-methylcrotonylurea (C₆H₁₀O₂N₂, MW 142, mp 213°) formed by heating BV with pyridine. From the above results it was clarified that the compound was different from synthetic and pyridine-treated compounds in infrared (IR) spectrum, nuclear magnetic resonance (NMR) spectrum, and thin-layer chromatogram. By more detailed analyses, this compound was determined to be 2-imino-5-isopropyl-4-oxazolidinone (OZ).
关键词：α-bromoisovalerylurea;5-isopropylhydantoin;3-methylcrotonylurea;2-imino-5-isopropyl-4-oxazolidinone;5-isopropyl-2, 4-oxazolidinedione;mass spectrum;NMR spectrum;IR spectrum;thin-layer chromatography