文章基本信息

标题：Kelthaneの生体内運命に関する研究(第1報)3H-Kelthaneのマウスにおける生体内分布と排泄
本地全文：下载
作者：金島弘恭 ; 奥井登代 ; 小川廣等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1980
卷号：26
期号：4
页码：192-195
DOI：10.1248/jhs1956.26.192
出版社：The Pharmaceutical Society of Japan
摘要：Distribution and excretion of ³H-1, 1-bis (4-chlorophenyl) 2, 2, 2-trichloroethanol (³H-kelthane) after oral dosaze were studied in mice. In the distribution study of ³H-kelthane, its radioactivity was detected in various tissues, indicating extensive uptake of this compound. The radioactivity distributed in each organ in mice reached a maximum after 24-48 hr and rapidly decreased thereafter with the exception of body fat. In particular, high level of radioactivity and its prolonged retention were observed in the body fat in mice. Approximately 60 % of the administered radioactivity was excreted in the urine (20 %) and feces (40 %) of mice within 96 hr, implying that fecal excretion is the major elimination route in the oral administration of kelthane.
关键词：kelthane;acaricide;tissue distribution;excretion;radioactivity