文章基本信息

标题：高速液体クロマトグラフィーによる乳液, クリーム類中のパラオキシ安息香酸エステル類の定量
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作者：三上栄一 ; 野田直希 ; 山田貞二等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1986
卷号：32
期号：1
页码：34-38
DOI：10.1248/jhs1956.32.34
出版社：The Pharmaceutical Society of Japan
摘要：A method for quantitative analysis of p-hydroxybenzoate esters (parabens) in cosmetic lotions and creams was developed by high-performance liquid chromatography (HPLC). Parabens were separated from the cosmetic base and other ingredients by bi-layer (upper ; celite, lower ; silica gel) column chromatography with Hexane-AcOEt (80 : 20). The eluate was extracted with acetonitrile. The acetonitrile layer was concentrated in vacuo and determined by HPLC on Develosil ODS by using a mobile phase of methanol-water (65 : 35, v/v). Recoveries of parabens obtained from model cosmetics were more than 95%. This method with clean-up procedure on bi-layer column chromatography and liquid extraction was much suitable for the determination of parabens in cosmetic lotions and creams.
关键词：HPLC;paraben;cosmetic;paraben determination;bi-layer column chromatography