文章基本信息

标题：最近の裁判化学における薬毒物分析の動向
本地全文：下载
作者：寺田賢
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1986
卷号：32
期号：3
页码：133-152
DOI：10.1248/jhs1956.32.133
出版社：The Pharmaceutical Society of Japan
摘要：This review surveys various chromatographic methods for the extraction and the determination of drugs and toxic compounds in biological and environmental materials reported during 1980-1985. The column liquid chromatographic methods by use of XAD-2, XAD-4, Extrelut, Clin Elut (Chem Elut), Sep Pak C₁₈, Bond Elut, Bio Beads SX-2 and SX-3 gel were applied to simple and rapid extraction and clean up of drugs and toxic compounds in biological and environmental materials. These chromatographic methods include high performance thin-layer chromatography, capillary gas chromatography, capillary gas chromatography-mass spectrometry (GC-MS), high performance liquid chromatography (HPLC) with photodiode array detection, high performance liquid chromatography-mass spectrometry, and isotachophoresis. Trace drugs and toxic compounds in biological and environmental materials were rapidly, sensitively and selectively detectable by HPLC with photodiode array detection, and capillary GC-MS.
关键词：analytical toxicology;column extraction;high performance thin-layer chromatography;fused silica capillary column;GC;GC-MS;negative ion chemical ionization;HPLC-MS;photodiode array detector;isotachophoresis