文章基本信息

标题：化学物質の経皮吸収と毒性 : 溶剤を中心として
本地全文：下载
作者：鶴田寛
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1986
卷号：32
期号：4
页码：229-241
DOI：10.1248/jhs1956.32.229
出版社：The Pharmaceutical Society of Japan
摘要：A critical factor in the evaluation of the risk associated with cutaneous exposure to chemical substances is an information relating to the percutaneous absorption of these substances. Recent developments in the percutaneous absorption of chemical substances in industry, especially organic solvents, are reviewed, and these percutaneous absorption rates in humans and animals exposed in vivo and their excised skin in vitro from vapor and liquid phase are summarized. Evaluations concerning the amounts of percutaneous absorption in vivo of organic solvents in toxicity are discussed by a mathematical model by using the percutaneous absorption coefficient for vapor phase and the percutaneous absorption rate for liquid phase, and recommendations for future research of organic solvents are proposed from the relationship between these chemical-physical properties and these percutaneous absorption rates.
关键词：percutaneous absorption;organic solvent;human;animal;toxicity;chemical substance;vapor;liquid