文章基本信息

标题：家庭用品による接触皮膚炎の原因化学物質の追求(第4報) : 市販ゴム製品中のメルカプトベンゾチアゾール系加硫促進剤の分析及びパッチテスト陽性率
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作者：鹿庭正昭 ; 五十嵐良明 ; 小嶋茂雄等
期刊名称：Journal of Health Science
印刷版ISSN：1344-9702
电子版ISSN：1347-5207
出版年度：1987
卷号：33
期号：2
页码：140-148
DOI：10.1248/jhs1956.33.140
出版社：The Pharmaceutical Society of Japan
摘要：A method for the determination of mercaptobenzothiazole-type accelerators (MBTs) was studied by reversed-phase high performance liquid chromatography (HPLC) with Nucleosil 5 C 18 column by using methanol-water (95 : 5) as a mobile phase. After extraction of rubber samples by shaking with an acetone-chloroform (1 : 1) mixture at room temperature, MBTs were analyzed by HPLC with ultraviolet (UV) detector at 275 nm before and after methylating with diazomethane. Two kinds of rubber sheets for medical use and 9 kinds of commercial rubber footwears (2 kinds of rubber boots and 7 kinds of shoes with rubber soles) were analyzed by the proposed method. Consequently, only 2-mercaptobenzothiazole (MBT) and/or dibenzothiazyl disulfide (MBTS) were found in all rubber samples. The ranges of contents were as follows : MBT, 21.7-1190 μg/g ; MBTS, 27.3-392 μg/g. Patch testing to MBTs was also studied in 40 patients with allergic contact dermatitis from rubber or poly vinyl chloride (PVC) materials (rubber group or PVC group), who were the same subjects in the previous papers. Generally speaking, rubber group reacted to MBTs in higher incidence than PVC group.
关键词：mercaptobenzothiazole-type accelerator determination;commercial rubber footwears;2-mercaptobenzothiazole;dibenzothiazyl disulfide;patch testing;positive reaction incidence