文章基本信息

标题：INHIBITORY EFFECTS OF HISTAMINE ON CONTRACTION INDUCED BY TRANSMURAL STIMULATION IN RAT VAS DEFERENS
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作者：PARK EUN-HEE ; HITOSHI KATO ; YUTAKA KASUYA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1978
卷号：1
期号：4
页码：268-270
DOI：10.1248/bpb1978.1.268
出版社：The Pharmaceutical Society of Japan
摘要：The effect of histamine on the contractions induced by neuromuscular transmission in the isolated rat vas deferens was investigated. Histamine, 10^-6-10-4M, showed a dose-dependent and reversible inhibition of the induced contractions. When the frequency of stimulation was altered(2.5-20Hz), the inhibitory effect tended to be marked at the lower frequencied. Contractions caused by norepinephrine, 10^-5M, were unaffected by histamine, indicating that the inhibitory effect of histamine was not due to a reduced sensitivity of the effector cells to the transmitter. Cimetidine, 7×10^-5M, diminished the response to histamine but chlorpheniramine, 10^-6M, did not. The results suggest that the inhibitory effect of histamine is mediated via H₂-receptors probably located at the adrenergic nerve terminal.
关键词：H2-receptor