文章基本信息

标题：CARRIER-MEDIATED TRANSPORT SYSTEMS FOR AMINOPENICIL-LINS IN RAT SMALL INTESTINE
本地全文：下载
作者：TOSHIKIRO KIMURA ; HAJIME ENDO ; MICHIYO YOSHIKAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1978
卷号：1
期号：4
页码：262-267
DOI：10.1248/bpb1978.1.262
出版社：The Pharmaceutical Society of Japan
摘要：The absorption of aminopenicillins from rat small intestine was investigated by using the in situ oerfsion technique. Carrier-mediated teansport systems were demonstrated for amonxicillin and cyclacillin. The absorption of amoxicillin and cyclacillin was saturable and inhibited by the short term pretreatment of the intestine with alow concentration of HgCl₂. The two penicillins inhibited intestinal absorption to each other. The simultaneous perfusion of dioeotides. L-phenylalanylglycine and glycycine, inhibited the absorption of cyclacillin but not of amoxicillin. Furthermore, only cyclacillin was shown to concentrate aganst agrabient. These data are consistent with the presence of two carrier systems for the active transport of cyclacillin in the intestinal mucosa : one which can be blocked by amoxicillin, and the other by bipeptides. Amoxicillin may be transported by the facilitated diffusion mechanism, the carrier of which seems to be common to one of the carrier systems for cyclacillin transport. No evidence of carrier-mediated transport of a, picillin could be found.
关键词：mutual inhibition