文章基本信息

标题：INFLUENCE OF PIPERIDINE AND PIPECOLIC ACID ON THE UPTAKE OF MONOAMINES, GABA AND GLYCINE INTO P2 FRACTIONS OF THE RAT BRAIN AND THE SPINAL CORD
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作者：YASUYUKI NOMURA ; YASUNOBU OKUMA ; TOMIO SEGAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1978
卷号：1
期号：4
页码：251-255
DOI：10.1248/bpb1978.1.251
出版社：The Pharmaceutical Society of Japan
摘要：Influence of piperidine and D, L-pipecolic acid, a hypnogenic amine and its possible precursor, on the uptake of L-[³H] noradrenaline (L-[³H] NA), [³H] dopamine ([³H] DA), [³H] 5-hydroxytryptamine ([³H] 5-HT), [¹⁴C] GABA and [¹⁴C] glycine into P₂, fractions of the rat brain and the spinal cord was investigated. Neither piperidine nor D, L-pipecolic acid affected the uptake of L-[³H] NA, [³H] DA, [³H] 5-HT and [¹⁴C] glycine at a dose of 10^-4M. On the other hand, D, L-pipecolic acid (10^-4 M). significantly (p<0.01) inhibited the [¹⁴C] GABA uptake but not piperidine (10^-4 M). These results suggest that a central cation of piperidine, e. g. sedation and sleep-prolongation, is not due to influence on the high affinity uptake mechanism of monoamines, GABA and glycine into synaptosomes in the central nervous system, and that pipecolic acid might interact with the GABA-ergic system as a neuromodulator.
关键词：glycine