文章基本信息

标题：PROINFLAMMATORY ACTIVITY OF COLCHICINE AS REVEALED IN RAT PAW EDEMA METHOD
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作者：KYUNG RAK MIN ; CHIKAKO MIZUNO ; SUSUMU TSURUFUJI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1979
卷号：2
期号：1
页码：1-4
DOI：10.1248/bpb1978.2.1
出版社：The Pharmaceutical Society of Japan
摘要：Colchicine, a microtubles-disrupting agent, when injected into subplantar region of the hind paw of rats, provoked an immediate elevation of the permeability of local vascular networks, resulting in a local tissue edema. The extent of the edema was dose-dependent. It was not affected at all by pretreatment of the rats with cyproheptadine, while cyproheptadine almost completely blocked formation of serotonin edema. When colchicine was applied together with serotonin, a synergistic enhancement of edema formation was observed. Colchicine and histamine were also synergistic.
关键词：synergism