文章基本信息

标题：EFFECT OF COMPLEXATION WITH DEXTRAN SULFATE ON THE LYMPHATIC DELIVERY OF BLEOMYCIN FOLLOWING INTRASTITIAL ADMINISTRATION
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作者：SHOZO MURANISHI ; YOSHITERU TAKAHASHI ; MITSURU HASHIDA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1979
卷号：2
期号：6
页码：383-390
DOI：10.1248/bpb1978.2.383
出版社：The Pharmaceutical Society of Japan
摘要：Enhanced delivery of bleomycin (BLM) into lymphatics by complexation with dextran sulfate was investigated following intramuscular and intragastric injection in rats. It was observed that the injection of the complex aqueous solution into muscle or stomach did not slow down the rate of disappearance from the site of injection. However, when the complex was protected from dissociation by incorporating into W/O emulsion system, intramuscular injection of BLM caused a slower disappearance from the tissue, and a more retarded plasma peak concentration than the complex aqueous solution or the emulsion system containing free BLM. Intragastric injection of the emulsion containing complex showed the most enhanced delivery of BLM into the regional lymph nodes. The results of this study suggest the exsistence of a special transport mechanism through which BLM is delivered together with dextran sulfate into lymphatics.
关键词：muscle