文章基本信息

标题：DRUG-CARRIER PROPERTY OF ALBUMIN MICROSPHERES IN CHEMOTHERAPY. III. EFFECT OF MICROSPHERE-ENTRAPPED 5-FLUOROURACIL ON EHRLICH ASCITES CARCINOMA IN MICE
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作者：KENJI SUGIBAYASHI ; MASAYUKI AKIMOTO ; YASUNORI MORIMOTO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1979
卷号：2
期号：6
页码：350-355
DOI：10.1248/bpb1978.2.350
出版社：The Pharmaceutical Society of Japan
摘要：To examine the possibility of utilizing albumin microspheres as drug-carriers, an in vitro release of 5-fluorouracil (5-FU) from albumin microspheres was examined and the effect of intraperitoneally injected drug-carrying microspheres on Ehrlich ascites carcinoma in mice was studied. In vitro release characteristics determined by dialysis experiments showed that 5-FU release continued over one week. We also noted that drug release in the peritoneum of ascites-bearing mice continued over one week and that their life-span increased. Furthermore, the microspheres were phagocytized in vivo by the ascites cells. Our results suggest that albumin microspheres containing 5-FU may represent an effective system of drug delivery with prolonged action.
关键词：tumor cell