文章基本信息

标题：STRUCTURE-ACTIVITY RELATIONSHIPS FOR THE INHIBITION OF FORMATION OF ACID-FASTNESS IN MYCOBACTERIAL ORGANISMS BY COUMARINS AND CINNAMATES
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作者：YOSHIKAZU KONDO ; TOMOHIRO TOIDA ; GENJIRO KUSANO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1980
卷号：3
期号：1
页码：41-45
DOI：10.1248/bpb1978.3.41
出版社：The Pharmaceutical Society of Japan
摘要：The relationships between the structure and inhibitory activity against the formation of acid-fastness in mycobacterial organisms were investigated in naturally occurring or synthetic coumarins and cinnamates. The presence of an OH-group at C₇ in the coumarin nucleus proved to be essential for the inhibitory activity. Likewise, the presence of a para-OH-group in cinnamates is also essential. Reduction of a conjugated α, β-double bond in both series resulted in a decrease of the ininhibitory activity. Shortening of the side chain of cinnamates resulted in total loss of the activity. The grouping 〓〓CO₂R appeared to be necessary for retaining the inhibitory activity.
关键词：cinnamates