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标题：MODIFLED DISTRIBUTION OF METHYLMERCURY BY ADDITIONAL EXPOSURE TO ELEMENTAL MERCURY OR MERCURIC CHLORIDE IN MICE FED METHYLMERCURIC CHLORIDE
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作者：REIKO YAMAMOTO ; HIROSHI SATOH ; TSUGUYOSHI SUZUKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1980
卷号：3
期号：2
页码：80-84
DOI：10.1248/bpb1978.3.80
出版社：The Pharmaceutical Society of Japan
摘要：Male IVCS mice fed pellets containing 8 nmol methylmercuric chloride (MMC)/g feed for 32 days were additionally inhaled elemental mercury vapor (Hg°) or injected mercuric chloride (Hg²⁺). The modified distribution of accumulated organic mercury was observed 24 hr after exposure to inorganic mercurials. The body burden of organic mercury decreased significantly in MMC+Hg²⁺ treated mice and moderately (not significant) in MMC+Hg°treated mice when compared with MMC treated mice. In spite of the decreased body burden, the organic mercury levels in brain, kidneys and blood of MMC+Hg° treated mice, and in kidneys of MMC+Hg²⁺ treated mice were elevated. In bile, organic mercury concentration after Hg° or Hg²⁺ exposure was reduced. The decrease of the blood cells-to-plasma ratio of organic mercury in mice after Hg° exposure is in agreement with the data reported for workers exposed to mercury vapor.
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