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标题：EFFECT OF BLEOMYCIN, NEOCARZINOSTATIN, AND HYDROXYUREA ON THE PREFORMED CARRAGEENIN GRANULOMA IN RATS : MECHANISM OF HYALURONIC ACID ACCUMULATION BY BLEOMYCIN
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作者：ATSUSHI HONDA ; YOSHIHIKO UEKI ; YO MORI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1980
卷号：3
期号：3
页码：167-176
DOI：10.1248/bpb1978.3.167
出版社：The Pharmaceutical Society of Japan
摘要：In order to elucidate whether the effects of bleomycin on the production or accumulation of intercellular substances by rat carrageenin granuloma are specific to bleomycin or a general response of the granulomatous tissue to the substances interfering with DNA synthesis, we examined the wet (or dry) weight and various components (DNA and glycosaminoglycans) in the granulomatous tissue of rats treated with bleomycin, neocarzinostatin, or hydroxyurea. The changes in various parameters of the granuloma after withdrawal of the inhibitors of DNA synthesis were different with different inhibitors tested. The highest recovery rate of DNA contents in the granulomatous tissue observed after withdrawal of bleomycin. It was also found that bleomycin caused much higher accumulation of hyaluronic acid in rat carrageenin granuloma than neocarzinostatin or hydroxyurea. This accumulation mechanism was indicated to be the results of the inhibition of mucopolysaccharidase activities via cells rather than those of the stimulation of glycosaminoglycan synthesis. These findings obtained in our experimental granuloma-system are of particular importance in considering the mechanism of the side effects of bleomycin.
关键词：side effects of bleomycin