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标题：SODIUM ION-DEPENDENCY OF TAURINE-INDUCED ENHANCEMENT OF DRUG ABSORPTION FROM RAT STOMACH IN SITU
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作者：TOSHIKIRO KIMURA ; KYUNG KIM ; HITOSHI SEZAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：3
页码：232-233
DOI：10.1248/bpb1978.4.232
出版社：The Pharmaceutical Society of Japan
摘要：The enhancement of aspirin and o-ethoxybenzoic acid (but not salicylamide) absorption by taurine was cancelled by the complete replacement of NaCl with mannitol or by the presence of ouabain in the NaCl medium. It seems to require Na⁺. Homotaurine showed a similar mode of action, while the effect of glycine, the other absorption promoter, on both aspirin and salicylamide absorption was independent of the presence of Na⁺. The mechanism of action of these amino acid-like absorption promoters is speculated to be not uniform.