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标题：GLUCOSE TOLERANCE CURVES IN GENETICALLY DIABETIC KKCAy MICE : THE PHARMACOKINETIC ANALYSIS FOR HUMPING EFFECT
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作者：MASAYASU KIMURA ; JUN SUZUKI ; TAMOTSU KOIZUMI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：3
页码：149-161
DOI：10.1248/bpb1978.4.149
出版社：The Pharmaceutical Society of Japan
摘要：Pharmacokinetic analysis on glucose tolerance curves in genetically diabetic KK-CA^y mice treated with hypoglycemics was investigated using an analog computer. The glucose tolerance curves in KK-CA^y mice showed humping phenomena. They could not be simulated by a simple compartmental model, but might be fitted to the model containing the non-linear function."Compartment-H" model was contrived by adding the H-factor between glucose and insulin compartments. All the glucose tolerance curves in the KK-CA^y mice could be simulated reasonably by this model and some suggestions on the humping effect were obtained from the analysis of H-factor. The H-factor was observed to be influenced by adrenergic α-blocker. This pharmacokinetic approach was indicated to be useful for the pharmacological research.
关键词：Compartment-H model