文章基本信息

标题：CHARACTERIZATION OF AMINOINDAMINES AND AMINOINDOANILINES FORMED BY OXIDATIVE HAIR DYEING AND THEIR MUTAGENICITY
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作者：YASUHIKO MATSUKI ; KATSUHARU FUKUHARA ; YASUYUKI INOUE 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：4
页码：269-274
DOI：10.1248/bpb1978.4.269
出版社：The Pharmaceutical Society of Japan
摘要：2-Amino-5-methoxy-2'(or 3')-methylindamine and 2-amino-5-methoxy-2'(or 3')-methylindoaniline were isolated from a coloring matter formed by oxidative condensation of 2, 5-diaminotoluene with 2, 4-diaminoanisole, and their structures were elucidated on the basis of nuclear magnetic resonance and mass spectral data. These two main components of the oxidation product formed at the early stage exhibited a positive result in the mutagenicity test on the thin-layer chromatography plate. The mutagenic activities of purified aminoindamines and aminoindoanilines against Salmonella typhimurium TA 98 were as strong as that of 2-acetamidofluorene. It was also demonstrated that 5-methoxy-2'(or 3')-methylindamine was formed in 10% yield under the conditions used for hair dyeing and the yield was dependent upon the molar ratio of 2, 5-diaminotoluene to 2, 4-diaminoanisole.
关键词：Salmonella typhimurium TA 98