文章基本信息

标题：ACUTE EFFECT OF METHAMPHETAMINE ON HEME OXYGENASE ACTIVITY AND ON CYTOCHROME P-450 CONTENT IN THE LIVER OF FEMALE RATS
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作者：KAZUHISA HAMASAKI ; TOSHIHIKO ARIYOSHI
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：5
页码：374-376
DOI：10.1248/bpb1978.4.374
出版社：The Pharmaceutical Society of Japan
摘要：After a single treatment with d-methamphetamine (philopon) at a dose of 8 mg/kg in 10 weeks old female Wistar rats, heme oxygenase activity was enhanced at 3 hr and reached its peak level at 12 hr, whereas cytochrome P-450 content showed the lowest level at 12 hr. However, activity of δ-aminolevulinic acid synthetase was not affected. Twenty-four hr later, all measured parameters returned to nearly initial levels at zero time. The pretreatment with cycloheximide blocked the increase of heme oxygenase activity in philopon-treated animals.
关键词：rat liver