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标题：SIGNIFICANCE OF 17-HYDROXYCORTICOSTEROIDS GLUCURONIDE IN URINE AS AN INDEX OF SALICYLAMIDE GLUCURONIDATION IN GUINEA PIGS
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作者：YASUFUMI SAWADA ; MASAHIRO HAYASHI ; SHOJI AWAZU 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：11
页码：893-900
DOI：10.1248/bpb1978.4.893
出版社：The Pharmaceutical Society of Japan
摘要：The glucuronidation of 17-hydroxycorticosteroids (17-OHCS) and its effectiveness as an index of salicylamide (SAM) glucuronidation were examined in guinea pigs, the same cortisol type animals as man, treated with carbon tetrachloride (CCl₄), D-galactosamine, phenobarbital, D, L-ethionine and alloxan. There was not a statistically significant correlation between the plasma clearance of SAM glucuronidation (CL_glu) and the urinary excretion ratio of 17-OHCS glucuronide to total 17-OHCS in the intact, and CCl₄, D-galactosamine, alloxan and D, L-ethionine treated guinea pigs (r=0.158). However, there was a statistically significant correlation between the CL_glu and the clearance of 17-OHCS glucuronidation obtained as urinary 17-OHCS glucuronide/plasma cortisol concentration (r=0.738, p < 0.1). It was proposed that the clearance of 17-OHCS glucuronide metabloized from endogenous cortisol could be used as an index to assess the drug glucuronidation activity.
关键词：phenobarbital