文章基本信息

标题：THE STRUCTURE-HEMOLYSIS RELATIONSHIP OF OLEANOLIC ACID DERIVATIVES AND INHIBITION OF THE SAPONIN-INDUCED HEMOLYSIS WITH SAPOGENINS
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作者：JUNICHI HASE ; KYOICHI KOBASHI ; KENICHIRO MITSUI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：11
页码：833-837
DOI：10.1248/bpb1978.4.833
出版社：The Pharmaceutical Society of Japan
摘要：Chikusetsusaponin IV and V, whose genin is oleanolic acid, exhibited weak hemolytic activities. Removal of glucose residue at position 28 of chikusetsusaponin V by partial hydrolysis increased the activity more than 30-fold. Methylation of the carboxyl group at position 28 increased the activity furthermore by about 10-fold, showing HD₅₀ value of 3.77 μM. On the other hand, removal of the sugar chain at position 3 of chickusetsusaponin V by partial hydrolysis completely lost the activity. These facts suggest that the sugar chain at position 3 of oleanolic acid is essential but that at position 28 is pernicious for the activity. The cytolytic agents, whose target has been regarded as membrane cholesterol, were inactivated not only by cholesterol but also by sapogenins such as oleanolic acid, gitogenin and hederagenin. Among saponins tested, akebia saponin B and C were inactivated by cholesterol, but not by the genins, probably because their affinities for the genins are too low to form complexes.
关键词：ginseng