文章基本信息

标题：DEVELOPMENT OF TOLERANCE TO THE STIMULATORY EFFECT OF NEUROLEPTIC BUTYROPHENONES ON PITUITARY-ADRENAL ACTIVITY IN RATS
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作者：TACHIO AIMOTO ; MORIO KAIDA ; KATSUJI NUMAZAKI 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1981
卷号：4
期号：11
页码：827-832
DOI：10.1248/bpb1978.4.827
出版社：The Pharmaceutical Society of Japan
摘要：The effects of repeated administration of haloperidol (HAL) and clofluperol (CLO) on the responsiveness of pituitary-adrenal system to these drugs were studied in rats. Chronic treatment of animals with a daily i.p. dose of 5 μmol/kg of the drugs resulted in markedly attenuated responses of plasma corticosterone (CS) to challenge of the same dose of the same drug as compared to the acute treatment which caused a large increase in the plasma CS levels. Animals receiving a chronic HAL treatment showed a complete cross-tolerance to the stimulatory effect of CLO and a nearly complete cross-tolerance to that of chlorpromazine. The adrenal cortices of animals tolerant to HAL responded normally to exogenous ACTH. This result indicates that the tolerance to the stimulatory action of the butyrophenones may occur in the hypothalamo-pituitary axis.
关键词：tolerance