文章基本信息

标题：DURATION OF THE LOCAL ANESTHETIC EFFECT OF TETRACAINE HYDROCHLORIDE SOLUTIONS AND TETRACAINE IN MICROSPHERES
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作者：NAOKI WAKIYAMA ; KAZUHIKO JUNI ; MASAHIRO NAKANO 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1982
卷号：5
期号：1
页码：13-17
DOI：10.1248/bpb1978.5.13
出版社：The Pharmaceutical Society of Japan
摘要：The local anesthetic effect of tetracaine in polylactic acid microspheres was compared with that of tetracaine hydrochloride solutions. As a first step, the local anesthetic effect of 0.1 ml tetracaine hydrochloride solutions was examined at four concentrations in vivo. Then, the local anesthetic effect of 0.2 ml tetracaine hydrochloride solutions was compared with that of 0.1 ml tetracaine hydrochloride solutions. The more the amount of tetracaine, the stronger and longer was the local anesthetic effect. The local anesthetic effect of tetracaine in microspheres was much longer and lasted over 100 h.
关键词：biodegradable polymer