文章基本信息

标题：ANTITUMOR ACTIVITY OF 1-ACYLOXYMETHYL DERIVATIVES OF 5-FLUOROURACIL AGAINST L1210 LEUKEMIA
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作者：AKIO HOSHI ; MOTOKO INOMATA ; FUMIHIKO KANZAWA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1982
卷号：5
期号：3
页码：208-212
DOI：10.1248/bpb1978.5.208
出版社：The Pharmaceutical Society of Japan
摘要：Antitumor activity of 15 1-acyloxymethyl derivatives of 5-fluorouracil was examined by both intraperitoneal injection and oral administration in L1210 leukemia system. Therapeutic ratio for dodecanoyloxymethyl derivative by intraperitoneal injection was 23 which was greater than that for 5-fluorouracil (11). On the other hand, undecanoyloxymethyl derivative of 5-fluorouracil showed the highest therapeutic ratio (5. 8) when administered orally which was greater than that for 5-fluorouracil (1.9) and 1-(2-tetrahydrofuryl)-5-fluorouracil (1.0).
关键词：L1210 leukemia