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标题：STUDIES ON THE TRIMETHADIONE METABOLISM AS A TOOL FOR THE ASSESSMENT OF DRUG-METABOLIZING CAPACITY USING PLASMA AND URINE OF RATS PRETREATED WITH PHENOBARBITAL AND 3-METHYLCHOLANTHRENE
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作者：EINOSUKE TANAKA ; HARUKI KINOSHITA ; TAKEMI YOSHIDA 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：1982
卷号：5
期号：3
页码：162-171
DOI：10.1248/bpb1978.5.162
出版社：The Pharmaceutical Society of Japan
摘要：To determine whether concentrations of trimethadione (TMO) and its metabolite 5, 5-dimethyl-2, 4-oxazolidinedione (DMO) in plasma as well as in urine of rats are useful indicator of drug-metabolizing capacity or not, the following experiments were carried out. Plasma TMO and DMO concentrations were measured in phenobarbital (PB) or 3-methylcholanthrene (3-MC)-pretreated rats following the administration of TMO. In PB-pretreated rats, there was a good correlation between elimination rate constant (K_el and plasma DMO/TMO ratio ; r=0.991 at 1 h, r=0.967 at 2 h). However, there was no good correlation in 3-MC-pretreated rats (r=0.780 at 1 h, r=0.720 at 2 h). TMO and DMO excretion in PB and 3-MC pretreated rats following the administration of TMO were not significantly different in 24-h urine. These experiments, together with the previous findings, indicate that concentrations of TMO and DMO in plasma, but not in urine, in PB-pretreated rats may be a useful indicator of drug-metabolizing capacity.
关键词：d-glucaric acid